LEMP is an autosomal recessive inherited disease of the central nervous system, which is characeterised by progressive gait abnormalities including paw dragging and knuckling. dogs show lacks of coordination and generalised ataxia. As the disease progresses, affected dogs may become increasingly immobile within a few months. Researchers from the university of Bern and the university of Minnesota were able to identify two causative genetic mutations, one of them affects Leonbergers, and a second one which affects Rottweilers and Great Danes. A test is now available at Laboklin.
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Leukoencephalomyelopathy ( LEMP ). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Genotype: N / LEMP [ Heterozygous ]
The dog carries one copy of the mutant gene and one copy of the normal gene.
It is very unlikely that the dog will develop Leukoencephalomyelopathy ( LEMP ) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.
Carriers should only be bred to clear dogs.
Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Genotype: LEMP / LEMP [ Homozygous mutant ]
The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Leukoencephalomyelopathy ( LEMP ) and will pass the mutant gene to its entire offspring
Please watch the short video below regarding LEMP