Neuroaxonal Dystrophy in Spanish Water Dogs is an uncharacterized juvenile-onset genetic disorder that affect Spanish Water Dogs. Affected dogs exhibits various neurological deficits including gait abnormalities and behavioral deficits.
Symptoms include slowly progressing neurological signs starting between six and eleven months of age. Owners of affected dogs reported gait abnormalities, behavioral changes (dullness, nervousness, vocalization) and incontinence alone or in combination with uncontrolled defecation. Mild head tilt, generalized mild cerebellar ataxia with hypermetria of the thoracic limbs and absent to depressed patellar reflexed. Additionally, affected dogs displayed varying degrees of compulsory pacing, proprioceptive deficits, decreased menace, visual deficits, positional nystagmus and decreased muscle tone.
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Neuroaxonal Dystrophy ( NAD ). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Genotype: N / NAD [ Heterozygous ]
The dog carries one copy of the mutant gene and one copy of the normal gene.
It is very unlikely that the dog will develop Neuroaxonal Dystrophy ( NAD ) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.
Carriers should only be bred to clear dogs.
Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Genotype: NAD / NAD [ Homozygous mutant ]
The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Neuroaxonal Dystrophy ( NAD ) and will pass the mutant gene to its entire offspring