Juvenile Laryngeal Paralysis & Polyneuropathy (JLPP) is a genetic disease that affects the nerves. In affected dogs, JLPP starts with the longest nerves in the body, one of the longest nerves is the one that supplies the muscles of the voice box (larynx) leading to muscle weakness and laryngeal paralysis as the first symptom. The vocal folds vibrate noisily and can obstruct the flow of air into the lungs when the dog is exercised or when it is hot. The dog may also choke on their food or water or regurgitate, and this can cause pneumonia.
The disease then progresses to the next longest nerves which supply the muscles of the back legs resulting in difficulty getting up and wobbly gait, the hind limbs are followed by the front limbs.
Other symptoms include abnormalities in eye development.
Symptoms typically start after weaning age.
Trait of Inheritance
Juvenile Laryngeal Paralysis & Polyneuropathy (JLPP) is inherited as autosomal recessive trait. The test enables breeders to identify their dogs as Clear (N/N), Carriers (N/JLPP), or Affected (JLPP/JLPP), and this helps breeders to avoid having affected puppies while maintaining the diversity of the gene pool.
Genotype: N / N [ Homozygous normal ]
The dog is noncarrier of the mutant gene.
It is very unlikely that the dog will develop Juvenile Laryngeal Paralysis & Polyneuropathy (JLPP). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.
Genotype: N / JLPP [ Heterozygous ]
The dog carries one copy of the mutant gene and one copy of the normal gene.
It is very unlikely that the dog will develop Juvenile Laryngeal Paralysis & Polyneuropathy (JLPP) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.
Carriers should only be bred to clear dogs.
Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected (see table above)
Genotype: JLPP / JLPP [ Homozygous mutant ]
The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.
The dog is likely to develop Juvenile Laryngeal Paralysis & Polyneuropathy (JLPP) and will pass the mutant gene to its entire offspring
Below is a short Educational video on JLPP in Australia & Worldwide (Juvenile Laryngeal Paralysis & Polyneuropathy). Please Watch.